Publications
Hyunwoo's Google Scholar Page & Research Gate Page
2024
Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi
Hyun Woo Kim, Jin Woo Lee, Sang Hee Shim
Natural Product ReportsDihydrostilbenes and flavonoids from whole plants of Jacobaea vulgaris
Shinae Lee, Min-Gyung Son, Young-Mi Kim, Chae-Yeong An, Hyun Ji Kim, Piseth Nhoek, Pisey Pel, Hongic Won, Yoonkyung Lee, Narae Yun, Jin-Hyub Paik, Badamtsetseg Bazarragchaa, Hyun Woo Kim, Young Hee Choi, Won Keun Oh, Chang Hoon Lee, Young-Won Chin
Phytochemistry 222, 114107Streptomyces tagetis sp. nov., a chromomycin producing bacteria isolated from the roots of Tagetes patula
Geeta Chhetri, Myeong Ji Kim, Inhyup Kim, Duc VH Tran, Young-Woo Kim, Hyun Woo Kim (co-corresponding), Taegun Seo
Frontiers in Microbiology 15, 1361583PECAN Predicts Patterns of Cancer Cell Cytostatic Activity of Natural Products Using Deep Learning
Martha Gahl, Hyun Woo Kim, Evgenia Glukhov, William H Gerwick, Garrison W Cottrell
Journal of Natural Products (Available online)Mass spectrometry-based ginsenoside profiling: Recent applications, limitations, and perspectives
Hyun Woo Kim, Dae Hyun Kim, Byeol Ryu, You Jin Chung, Kyungha Lee, Young Chang Kim, Jung Woo Lee, Dong Hwi Kim, Woojong Jang, Woohyeon Cho, Hyeonah Shim, Sang Hyun Sung, Tae-Jin Yang, Kyo Bin Kang
Journal of Ginseng Research (Available online)
2023
Open access repository-scale propagated nearest neighbor suspect spectral library for untargeted metabolomics.
Wout Bittremieux, Nicole E Avalon, Sydney P Thomas, Sarvar A Kakhkhorov, Alexander A Aksenov, Paulo Wender P Gomes, Christine M Aceves, Andrés Mauricio Caraballo-Rodríguez, Julia M Gauglitz, William H Gerwick, Tao Huan, Alan K Jarmusch, Rima F Kaddurah-Daouk, Kyo Bin Kang, Hyun Woo Kim, Todor Kondić, Helena Mannochio-Russo, Michael J Meehan, Alexey V Melnik, Louis-Felix Nothias, Claire O’Donovan, Morgan Panitchpakdi, Daniel Petras, Robin Schmid, Emma L Schymanski, Justin JJ van der Hooft, Kelly C Weldon, Heejung Yang, Shipei Xing, Jasmine Zemlin, Mingxun Wang, Pieter C Dorrestein
Nature Communications, 14, 8488Artificial intelligence for natural product drug discovery
Michael W Mullowney, Katherine R Duncan, Somayah S Elsayed, Neha Garg, Justin JJ van der Hooft, Nathaniel I Martin, David Meijer, Barbara R Terlouw, Friederike Biermann, Kai Blin, Janani Durairaj, Marina Gorostiola González, Eric JN Helfrich, Florian Huber, Stefan Leopold-Messer, Kohulan Rajan, Tristan de Rond, Jeffrey A van Santen, Maria Sorokina, Marcy J Balunas, Mehdi A Beniddir, Doris A van Bergeijk, Laura M Carroll, Chase M Clark, Djork-Arné Clevert, Chris A Dejong, Chao Du, Scarlet Ferrinho, Francesca Grisoni, Albert Hofstetter, Willem Jespers, Olga V Kalinina, Satria A Kautsar, Hyunwoo Kim, Tiago F Leao, Joleen Masschelein, Evan R Rees, Raphael Reher, Daniel Reker, Philippe Schwaller, Marwin Segler, Michael A Skinnider, Allison S Walker, Egon L Willighagen, Barbara Zdrazil, Nadine Ziemert, Rebecca JM Goss, Pierre Guyomard, Andrea Volkamer, William H Gerwick, Hyun Uk Kim, Rolf Müller, Gilles P van Wezel, Gerard JP van Westen, Anna KH Hirsch, Roger G Linington, Serina L Robinson, Marnix H Medema
Nature Reviews Drug Discovery, 1-22DeepSAT: Learning Molecular Structures from Nuclear Magnetic Resonance Data
Hyun Woo Kim, Chen Zhang, Raphael Reher, Mingxun Wang, Kelsey L Alexander, Louis-Félix Nothias, Yoo Kyong Han, Hyeji Shin, Ki Yong Lee, Kyu Hyeong Lee, Myeong Ji Kim, Pieter C Dorrestein, William H Gerwick, Garrison W Cottrell
Journal of Cheminformatics, 15 (1), 1-12Change of metformin concentrations in the liver as a pharmacological target site of metformin after long-term combined treatment with ginseng berry extract
Choong Whan Lee, Byoung Hoon You, Sreymom Yim, Seung Yon Han, Hee-Sung Chae, Mingoo Bae, Seo-Yeon Kim, Jeong-Eun Yu, Jieun Jung, Piseth Nhoek, Hojun Kim, Han Seok Choi, Young-Won Chin, Hyun Woo Kim, Young Hee Choi
Frontiers in Pharmacology, 14, 1148155Alkaloids and Coumarins with Adiponectin-Secretion-Promoting Activities from the Leaves of Orixa japonica
Piseth Nhoek, Sungjin Ahn, Pisey Pel, Young-Mi Kim, Jungmoo Huh, Hyun Woo Kim, Minsoo Noh, Young-Won Chin
Journal of natural products, 86, 1, 138–148
2022
Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of Lysimachia vulgaris
Pisey Pel, Young-Mi Kim, Hyun Ji Kim, Piseth Nhoek, Chae-Yeong An, Min-Gyung Son, Hongic Won, Seung Eun Lee, Jeonghoon Lee, Hyun Woo Kim, Young Hee Choi, Chang Hoon Lee, Young-Won Chin
ACS omega, 7, 50, 47296–47305Standardized multi-omics of Earth’s microbiomes reveals microbial and metabolite diversity
Justin P Shaffer, Louis-Félix Nothias, Luke R Thompson, Jon G Sanders, Rodolfo A Salido, Sneha P Couvillion, Asker D Brejnrod, Shi Huang, Franck Lejzerowicz, Holly L Lutz, Qiyun Zhu, Cameron Martino, James T Morton, Smruthi Karthikeyan, Mélissa Nothias-Esposito, Kai Dührkop, Sebastian Böcker, Hyunwoo Kim, Alexander A Aksenov, Wout Bittremieux, Jeremiah J Minich, Clarisse Marotz, MacKenzie M Bryant, Karenina Sanders, Tara Schwartz, Greg Humphrey, Yoshiki Vásquez-Baeza, Anupriya Tripathi, Laxmi Parida, Anna Paola Carrieri, Niina Haiminen, Kristen L Beck, Promi Das, Antonio González, Daniel McDonald, Søren M Karst, Mads Albertsen, Gail Ackermann, Jeff DeReus, Torsten Thomas, Daniel Petras, Ashley Shade, James Stegen, Se Jin Song, Thomas O Metz, Austin D Swafford, Pieter C Dorrestein, Janet K Jansson, Jack A Gilbert, Rob Knight
Nature microbiology, 1-23Mass spectrometry data on specialized metabolome of medicinal plants used in East Asian traditional medicine
Kyo Bin Kang, Eunah Jeong, Seungju Son, Eunjin Lee, Seungjin Lee, Seong Yeon Choi, Hyun Woo Kim, Heejung Yang, Sang Hee Shim
Scientific Data 9 (1), 1-7Discovery of Novel Tyrosinase Inhibitors From Marine Cyanobacteria
Yifan He, Takashi L Suyama, Hyunwoo Kim, Evgenia Glukhov, William H Gerwick
Frontiers in Microbiology, 2324Chemical Constituents from the Roots and Rhizomes of Sophora tonkinensis and Their Effects on Proprotein Convertase Substilisin/Kexin Type 9 Expression
Pisey Pel, Hee-Sung Chae, Piseth Nhoek, Young-Mi Kim, Chae-Yeong An, Hunseung Yoo, Minseok Kang, Hyun Woo Kim, Young Hee Choi, Young-Won Chin
ACS OmegaCyclohumulanoid Sesquiterpenes Induced by the Noncompetitive Coculture of Phellinus orientoasiaticus and Xylodon flaviporus
Huong T Pham, Thi Phuong Doan, Hyun Woo Kim, Tae Wan Kim, So-Yeon Park, Hangun Kim, Mina Lee, Ki Hyun Kim, Won Keun Oh, Young Woon Lim, Kyo Bin Kang
Journal of Natural Products 85(3), 511-518Flavonostilbenes Isolated from the Stems of Rhamnoneuron balansae as Potential SIRT1 Activators
Hyo-Moon Cho, Mi Zhang, Eun-Jin Park, Ba-Wool Lee, Yeon-Joo Park, Hyun-Woo Kim, Ha-Thanh-Tung PhamHa-Thanh-Tung Pham, Young-Won Chin, and Won-Keun Oh
Journal of natural products 85(1), 70–82
2021
SMART‐Miner: A convolutional neural network‐based metabolite identification from 1H‐ 13C HSQC spectra
Hyun Woo Kim, Chen Zhang, Garrison W. Cottrell, William H. Gerwick
Magnetic Resonance in Chemistry (Early view)
Try this tool!: https://colab.research.google.com/drive/1d_oOze0krUXFEYQ4ttBGRTIlzlAnkrn8?usp=sharingNPClassifier: a deep neural network-based structural classification tool for natural products
Hyun Woo Kim, Mingxun Wang, Christopher A Leber, Louis-Félix Nothias, Raphael Reher, Kyo Bin Kang, Justin JJ Van Der Hooft, Pieter C Dorrestein, William H Gerwick, Garrison W Cottrell
Journal of natural products 84 (11), 2795-2807
Try this tool!: https://npclassifier.ucsd.eduSalicinoyl Quinic Acids and Their Prostaglandin E2 Production Inhibitory Activities from the Fruits of Casearia grewiifolia
Piseth Nhoek, Sungjin Ahn, In Guk Park, Pisey Pel, Jungmoo Huh, Hyun Woo Kim, Jongmin Ahn, Piseth Khiev, Young Hee Choi, Kyeong Lee, Minsoo Noh, Young-Won Chin
Journal of Natural Products 84 (9), 2437-2446SIRT1 Activation Enhancing 8, 3′-Neolignans from the Twigs of Corylopsis coreana Uyeki
Hyun Woo Kim, Jin-Bum Jeon, Mi Zhang, Hyo-Moon Cho, Byeol Ryu, Ba-Wool Lee, William H Gerwick, Won-Keun Oh
Plants 10 (8), 1684Sesquiterpenoids from the Aerial Parts of Salvia plebeia with Inhibitory Activities on Proprotein Convertase Subtilisin/Kexin Type 9 Expression
Piseth Nhoek, Hee-Sung Chae, Young-Mi Kim, Pisey Pel, Jungmoo Huh, Hyun Woo Kim, Young Hee Choi, Kyeong Lee, Young-Won Chin
Journal of Natural Products 84 (2), 220-229Metabolomic Approaches to Investigate the Effect of Metformin: An Overview
Hyun Woo Kim
International Journal of Molecular Science 22(19):10275Structure elucidation of a new triterpene from Inonotus obliquus
Sangmin Park, Hyeji Shin, Dawon Park, Hyunwoo Kim, Youngjoo Byun, Ki Yong Lee
Magnetic Resonance in Chemistry 59 (4), 489-494
2020
Glucose Uptake-Stimulating Galloyl Ester Triterpenoids from Castanopsis sieboldii
Hyun Woo Kim, Eun Jin Park, Hyo Moon Cho, Jin-Pyo An, Young Won Chin, Jinwoong Kim, Sang Hyun Sung, Won Keun Oh
Journal of Natural Products 83 (10), 3093-3101Characterization of anti-inflammatory and antioxidant constituents from Scutellaria baicalensis using LC-MS coupled with a bioassay method
Yoo Kyong Han, Hyunwoo Kim, Hyeji Shin, Jiyeon Song, Mi Kyeong Lee, Byoungduck Park, Ki Yong Lee
Molecules 25 (16), 3617Combined MS/MS-NMR annotation guided discovery of Iris lactea var. chinensis seed as a source of viral neuraminidase inhibitory polyphenols
Hyun Woo Kim, Soo Sung Kim, Kyo Bin Kang, Byeol Ryu, Eunjin Park, Jungmoo Huh, Won Kyung Jeon, Hee-Sung Chae, Won Keun Oh, Jinwoong Kim, Sang Hyun Sung, Young-Won Chin
Molecules 25 (15), 3383A convolutional neural network-based approach for the rapid annotation of molecularly diverse natural products
Raphael Reher*, Hyun Woo Kim*, Chen Zhang*, Huanru Henry Mao, Mingxun Wang, Louis-Félix Nothias, Andres Mauricio Caraballo-Rodriguez, Evgenia Glukhov, Bahar Teke, Tiago Leao, Kelsey L Alexander, Brendan M Duggan, Ezra L Van Everbroeck, Pieter C Dorrestein, Garrison W Cottrell, William H Gerwick
Journal of the American Chemical Society 142 (9), 4114-4120 *Authors Contributed Equally
Try this tool!: https://smart.ucsd.edu/classicUnique triterpenoid of jujube root protects cisplatin-induced damage in kidney epithelial LLC-PK1 cells via autophagy regulation
Dahae Lee, Kyo Bin Kang, Hyun Woo Kim, Jung Sik Park, Gwi Seo Hwang, Ki Sung Kang, Sungyoul Choi, Noriko Yamabe, Ki Hyun Kim
Nutrients 12 (3), 677Pagoamide A, a Cyclic Depsipeptide Isolated from a Cultured Marine Chlorophyte, Derbesia sp., Using MS/MS-Based Molecular Networking
Yueying Li, Hao-Bing Yu, Yi Zhang, Tiago Leao, Evgenia Glukhov, Marsha L Pierce, Chen Zhang, Hyunwoo Kim, Huanru Henry Mao, Fang Fang, Garrison W Cottrell, Thomas F Murray, Lena Gerwick, Huashi Guan, William H Gerwick
Journal of natural products 83 (3), 617-625
2019
Dereplication by High-Performance Liquid Chromatography (HPLC) with Quadrupole-Time-of-Flight Mass Spectroscopy (qTOF-MS) and Antiviral Activities of Phlorotannins from Ecklonia cava
Hyo Moon Cho, Thi Phuong Doan, Thi Kim Quy Ha, Hyun Woo Kim, Ba Wool Lee, Ha Thanh Tung Pham, Tae Oh Cho, Won Keun Oh
Marine drugs 17 (3), 149In Silico Annotation of Discriminative Markers of Three Zanthoxylum Species Using Molecular Network Derived Annotation Propagation
Jiho Lee, Ricardo R da Silva, Hyeon Seok Jang, Hyun Woo Kim, Yong Soo Kwon, Jung-Hwan Kim, Heejung Yang
Food chemistry 295, 368-376Exploring Novel Secondary Metabolites from Natural Products using Pre-Processed Mass Spectral Data
Hyun Woo Kim, Seong Yeon Choi, Hyeon Seok Jang, Byeol Ryu, Sang Hyun Sung, Heejung Yang
Scientific reports 9 (1), 1-11Development of a Building Block Strategy to Target the Classification, Identification, and Metabolite Profiling of Oleanane Triterpenoids in Gymnema sylvestre Using UHPLC-qTOF/MS
Ha-Thanh-Tung Pham, Hyun-Woo Kim, Sohee Han, Byeol Ryu, Thi-Phuong Doan, Jin-Pyo An, Van-On Tran, Won-Keun Oh
Journal of natural products 82 (12), 3249-3266Eudesmane Glycosides from Ambrosia artemisiifolia (Common Ragweed) as Potential Neuroprotective Agents
Jin-Pyo An, Thi Kim Quy Ha, Hyun Woo Kim, Byeol Ryu, Jinwoong Kim, Junsoo Park, Chul Ho Lee, Won Keun Oh
Journal of natural products 82 (5), 1128-1138
2013-2018
A standardized herbal extract PM014 ameliorates pulmonary fibrosis by suppressing the TGF-β1 pathway
Kyung Hwa Kim, Sujin Lee, Hyunji Lee, Dasom Shin, Daeun Min, Miran Kim, Byeol Ryu, Hyeon Woo Kim, Hyunsu Bae
Scientific reports 8 (1), 1-12Targeted Isolation of Neuroprotective Dicoumaroyl Neolignans and Lignans from Sageretia theezans Using in Silico Molecular Network Annotation Propagation-Based Dereplication
Kyo Bin Kang, Eun Jin Park, Ricardo R da Silva, Hyun Woo Kim, Pieter C Dorrestein, Sang Hyun Sung
Journal of natural products 81 (8), 1819-1828Terminalia chebula extract prevents scopolamine-induced amnesia via cholinergic modulation and anti-oxidative effects in mice
Min-Soo Kim, Dong Young Lee, Jun Lee, Hyun Woo Kim, Sang Hyun Sung, Jung-Soo Han, Won Kyung Jeon
BMC Complementary and Alternative Medicine 18 (1), 1-11Ceanothane-and lupane-type triterpene esters from the roots of Hovenia dulcis and their antiproliferative activity on HSC-T6 cells
Kyo Bin Kang, Jin Bum Jun, Jung Wha Kim, Hyun Woo Kim, Sang Hyun Sung
Phytochemistry 142, 60-67Fast and Simple Discriminative Analysis of Anthocyanins‐Containing Berries Using LC/MS Spectral Data
Heejung Yang, Hyun Woo Kim, Yong Soo Kwon, Ho Kyong Kim, Sang Hyun Sung
Phytochemical Analysis 28 (5), 416-423Hepatoprotective flavonoids in Opuntia ficus-indica fruits by reducing oxidative stress in primary rat hepatocytes
Jung Wha Kim, Tae Bum Kim, Hyun Woo Kim, Sang Wook Park, Hong Pyo Kim, Sang Hyun Sung
Pharmacognosy Magazine 13 (51), 472Hydrolyzable tannins from the fruits of Terminalia chebula Retz and their α-glucosidase inhibitory activities
Dong Young Lee, Hyun Woo Kim, Heejung Yang, Sang Hyun Sung
Phytochemistry 137, 109-116Catechin-Bound Ceanothane-Type Triterpenoid Derivatives from the Roots of Zizyphus jujuba
Kyo Bin Kang, Hyun Woo Kim, Jung Wha Kim, Won Keun Oh, Jinwoong Kim, Sang Hyun Sung
Journal of natural products 80 (4), 1048-1054New polyhydroxytriterpenoid derivatives from fruits of Terminalia chebula Retz. and their α-glucosidase and α-amylase inhibitory activity
Dong Young Lee, Heejung Yang, Hyun Woo Kim, Sang Hyun Sung
Bioorganic & Medicinal Chemistry Letters 27 (1), 34-39Cytotoxic activities of naturally occurring oleanane-, ursane-, and lupane-type triterpenes on HepG2 and AGS cells
Heejung Yang, Hyun Woo Kim, Young Choong Kim, Sang Hyun Sung
Pharmacognosy Magazine 13 (49), 118Acylphloroglucinolated Catechin and Phenylethyl Isocoumarin Derivatives from Agrimonia pilosa
Hyun Woo Kim, Junha Park, Kyo Bin Kang, Tae Bum Kim, Won Keun Oh, Jinwoong Kim, Sang Hyun Sung
Journal of Natural Products 79 (9), 2376-2383Preparative purification of anti-proliferative diarylheptanoids from Betula platyphylla by high-speed counter-current chromatography
Namki Cho*, Hyun Woo Kim*, Tae Bum Kim, Tanya T Ransom, John A Beutler, Sang Hyun Sung
Molecules 21 (6), 700 *Authors Contributed EquallyInhibition of nitric oxide production in BV2 microglial cells by triterpenes from Tetrapanax papyriferus
Namki Cho, Eun Hye Moon, Hyun Woo Kim, Jaewoo Hong, John A Beutler, Sang Hyun Sung
Molecules 21 (4), 459Salvia miltiorrhiza extract protects white matter and the hippocampus from damage induced by chronic cerebral hypoperfusion in rats
Min-Soo Kim, Ji Hye Bang, Jun Lee, Hyeon Woo Kim, Sang Hyun Sung, Jung-Soo Han, Won Kyung Jeon
BMC Complementary and Alternative Medicine 15 (1), 1-10Ameliorative effect of betulin from Betula platyphylla bark on scopolamine-induced amnesic mice
Namki Cho, Hyeon Woo Kim, Hee Kyoung Lee, Byung Ju Jeon, Sang Hyun Sung
Bioscience, biotechnology, and biochemistry 80 (1), 166-171The effects of Betula platyphylla bark on amyloid beta-induced learning and memory impairment in mice
Namki Cho, Hee Kyoung Lee, Byung Ju Jeon, Hyeon Woo Kim, Hong Pyo Kim, Jong-Hwan Lee, Young Choong Kim, Sang Hyun Sung
Food and chemical toxicology 74, 156-163Isolation and structure elucidation of (−)-idescarparide, a new spiro compound from Idesia polycarpa
Tae Bum Kim, Hyeon Woo Kim, Mina Lee, Hyang Hwa Lee, Seung Hyun Kim, Sung Kwon Kang, Sang Hyun Sung
Tetrahedron Letters 55 (40), 5447-5449Neuroprotective Benzyl Benzoate Glycosides from Disporum viridescens Roots in HT22 Hippocampal Neuronal Cells
Namki Cho, Heejung Yang, Mina Lee, Jungmoo Huh, Hyeon-Woo Kim, Hong-Pyo Kim, Sang-Hyun Sung
Journal of Natural Products 76 (12), 2291-2297